New compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3'diindolylmethane (LTr-1), acceptable carriers and/or excipients. These compositions are administered to prevent or reduce symptoms associated with mastalgia, endometriosis and HPV-related conditions including cervical dysplasia.

The invention provides methods and compositions for diagnosing and treating ectodermal disorders, particularly ectodermal dysplasia syndromes such as Clouston syndrome, which are associated with misexpression of a TAJ gene. Methods detect the presence of or predisposition to an ectodermal disorder by (a) detecting the presence of a TAJ gene or gene product in a cell; and (b) correlating the presence of the TAJ gene or gene product with a presence of or predisposition to an ectodermal disorder. O...

A method for determining the hip joint laxity of a dog includes the steps of positioning the hip joints of the dog, in a coordinate system having three degrees of freedom, a first degree of freedom for flexion and extension of the hip joint, a second degree of freedom for adduction and abduction of the hip joint, and a third degree of freedom for internal and external rotation of the hip joint, where a neutral position is defined as positioning of an axis of the femur perpendicular to a plane de...

The invention relates to a pharmaceutical composition comprising copper sulfate as active agent which is effective for the diagnosis and treatment of genital dysplasia associated with viral condylomatosis. The invention also relates to a method for treating patients with the copper sulfate composition of the invention for detecting the existence of genital dysplasia and for curing such abnormality in the human organism.

The DNA and amino acid sequences are disclosed for a ligand (EDA1-II) and receptor (dl in mice and DL in humans) involved in ectodermal dysplasia. Also disclosed are variant DNA and amino acid sequences, and therapeutic applications of the ligands and receptors.

A method for measuring functional laxity in a dog for determining presence of or absence of canine hip dysplasia is provided by placing the dog in a weight-bearing position; and assessing hip joint subluxation by an imaging technique by estimating a degree of dorsolateral subluxation for each hip joint of the positioned dog, with the degree of dorsolateral subluxation determined by measuring the portion of femoral head medial to the acetabulum. Also provided is an apparatus for placement and pos...

A method of detecting dysplastic regions within epithelial tissue samples is sensitive enough to detect and distinguish between low grade and high grade dysplastic regions. The method uses probes specific for expression and accumulation of substances within a particular intracellular region from a defect in apical membrane trafficking (trafficking markers) and in the preferred embodiment correlates the trafficking marker levels with the presence of an oncogene such as p53. If low grade dysplasia...

Primary screening for cervical dysplasia is effected by measuring a biochemical marker of apoptosis and/or angiogenesis in each of a population of cells derived from convenient, superficial swabbing, sponging, scraping or lavage of superficial epithelial cells from the cervix, wherein the marker indicates the presence of cervical dysplasia in the sample, and scoring the results of the measuring step for cervical dysplasia (i.e. ascertaining whether or not the marker is present) in the patient in...

In an orthopedic device for treating hip dysplasia and hip dislocation, a pelvis-supporting portion is provided with two angular projections extending in the region of natural hip joints of a patient and each carrying a pivot joint including rotation discs to which a curved guide is connected. The curved guide of each pivot joint has a longitudinal slot in which an end of an upper shank guide bar is displaceable and arrestable in any desired position. Two upper shank guide bars carrying the resp...

A prosthetic device suitable for treating canine hip dysplasia and lumbosacral disorders and method of use. The prosthetic device comprises a harness attachable to the canine. Complementary rear braces are provided comprising a right brace and a left brace wherein the right brace comprises a right leg strap for encircling the right leg of the canine, and the left brace comprises a left leg strap for encircling the left leg of the canine. The right brace and left brace are engageable to apply for...